Direct Supervisor:  Douglas S. Kwon, MD PhD, Assistant Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge:  PhD and/or MD with experience in immunology
Years experience required:  At least 3 years of doctoral research experience

Summary:
The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston has an opening for a highly motivated postdoctoral fellow to study alterations in the microbiome that occur with HIV infection, following up on recent studies published by our group in Immunity, The Lancet Infectious Diseases, and Cell Host and Microbe (see further details here).  This includes examination of the role of the microbiome in the female genital tract and gut and the impact of these changes on host mucosal immunity. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research involving transcriptional and immunologic profiling of mucosal immune populations and the microbiome with the aim of generating new approaches to treat and prevent HIV infection using samples from well-characterized cohorts in the U.S. and sub-Saharan Africa. The position will also involve the use of novel in vivo model system, such as germ-free and humanized mice.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptional research setting.

Job Duties:
Under the direction of the principal investigator, the applicant will independently carry out activities performing laboratory research. Duties include:

• Guide research projects through experimental design, conduct experiments, and analysis of data
• Maintain detailed documentation of the experimental work
• Present data within and outside of the laboratory group at meetings and symposia
• Work closely within the group and with outside collaborators
• Mentor students and technicians
• Maintain close communications with the PI regarding progress
• Write, edit, and submit manuscripts/abstracts detailing the results of the project
• Demonstrate integrity, excellence, accountability and teamwork in all interactions

Qualifications:

• A Ph.D. and/or M.D. with relevant experience in immunology, murine models, and/or transcriptional profiling preferred
• Experience with flow cytometry, cell culture
• Prior work with murine models preferred
• Highly motivated and independent, with the ability to work in a dynamic team environment
• Exceptional organizational skills and excellent attention to detail
• Strong oral and written communications skills
• Must have good interpersonal skills
• Occasional weekend or evening flexibility

Application information: The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries.  All applicants, including those from abroad, must be able to come to Cambridge, MA USA for an in-person interview.

Direct Supervisor:  Doug S. Kwon, MD PhD, Associate Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Website: www.kwonlab.org

Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge: PhD and/or MD with experience in immunology, microbiology and/or computational approaches
Years experience required: At least 3 years of doctoral research experience

Summary:
The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston has an opening for a highly motivated postdoctoral fellow to study mechanistic links between the vaginal microbiome and adverse reproductive outcomes, following up on recent studies published by our group in Immunity, The Lancet Infectious Diseases, and Cell Host and Microbe (see further details here).  This includes examination of the role of the vaginal microbiome that impact host mucosal immunity and HIV acquisition risk. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research using samples from well characterized cohorts in the U.S. and sub-Saharan Africa involving transcriptional and immunologic profiling of mucosal immune populations and the microbiome using novel technologies, with the aim of generating new approaches to treat and prevent HIV infections. This includes the use of novel murine models to perform mechanistic studies of the role of mucosal immunity in the female genital tract on HIV susceptibility.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptional research setting.

Job Duties: Under the direction of the principal investigator, the applicant will independently carry out activities performing laboratory research. Duties include:

• Guide research projects through experimental design, conduct of experiments, and analysis of data
• Maintain detailed documentation of the experimental work
• Present data within and outside of the laboratory group at meetings and symposia
• Work closely within the group and with outside collaborators
• Mentor students and technicians
• Maintain close communications with the PI regarding progress
• Write, edit, and submit manuscripts/abstracts detailing the results of the project
• Demonstrate integrity, excellence, accountability and teamwork in all interactions

Ideal Qualifications:

• A Ph.D. and/or M.D. with relevant experience in immunology and mouse work preferred
• Experience with flow cytometry, cell culture
• Highly motivated and independent, with the ability to work in a dynamic team environment
• Exceptional organizational skills and excellent attention to detail
• Strong oral and written communications skills
• Must have good interpersonal skills
• Prior work with murine models

Application information: The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries. All applicants, including those from abroad, must be able to come to Cambridge, MA USA for an in-person interview.

Direct Supervisor:  Douglas S. Kwon, MD PhD, Assistant Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge: PhD required

Years experience required: 3 or more years of relevant experience

Summary:

The Ragon Institute is a highly unique, innovative, and collaborative research center at the forefront of biomedical science. Founded by Massachusetts General Hospital, MIT, and Harvard, the Ragon vision is a bold one: to harness the power of the immune system to prevent and cure human disease on a global scale. This vision is pursued and advanced every day by a group of highly motivated individuals. The Ragon Institute, at every level, depends upon collaboration, compassion, dedication, and innovation.  It is a results-oriented organization that seeks people who not only embrace these values but who thrive in teams and want to work in a dynamic environment.

The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston has an opening for a highly motivated postdoctoral fellow to study host-microbe interactions in the female reproductive tract that impact human health.  The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research involving curated, high dimensional, multiomics data integration, including analysis of metagenomics, metatranscriptomics, metabolomics, host single cell transcriptomics and clinical metadata. Projects will utilize large, well characterized patient cohorts based in the US and sub-Saharan Africa to understand host-microbiota interactions and their impact on HIV, pregnancy, fertility, TB, and cancer.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptionally energetic research setting at the Ragon Institute, which is part of Massachusetts General Hospital, the Massachusetts Institute of Technology, and Harvard Medical School. We are a mission-oriented group of highly motivated scientists from the fields of immunology, microbiology, virology, genetics, and technology development who perform translational research.

Job Duties:

Under the direction of the principal investigator, the applicant will independently carry out activities performing research. Specifically, a large effort in the lab is underway to integrate and analyze a multiomic dataset from thousands of samples from a prospective study with thousands of participants of the vaginal microbiome, mucosal immune state, and health outcomes. Duties include:

• Integrate and organize existing data from many modalities, including 16S amplicons, shotgun metagenomics, multiplex ELISA, metabolomics, and more.
• Interface with researchers in the lab generating new data and continuously process raw data to assess the quality of new data
• Lead the biological analysis and interpretation of the data of these multiple modalities
• Work closely within the group and with outside collaborators
• Mentor students and technicians
• Maintain close communications with the PI regarding progress
• Write, edit, and submit manuscripts/abstracts detailing the results of the project
• Demonstrate integrity, excellence, accountability and teamwork in all interactions

Qualifications:

• A Ph.D. and/or M.D. with relevant experience in microbiome characterization and relevant computational approaches required
• Experience in integrating multiple data types from many samples, with an understanding of raw-data generation and bioinformatic processing, as well as downstream analysis of high-dimensional multimodal data.
• Highly motivated and independent, with the ability to work in a dynamic team environment
• Exceptional organizational skills and excellent attention to detail
• Strong oral and written communications skills
• Must have good interpersonal skills

The above job description details the major duties and qualifications of the listed position. The individual hired to this position confirms that they are able to perform all duties outlined. Although the specific duties and responsibilities of this position may vary slightly, the supervisor of this position will ensure that the individual hired to this position is trained and qualified to complete each task assigned.

Application information: Please send your resume, cover letter, and contact information for three references to Dr. Doug Kwon (dkwon@mgh.harvard.edu).

 

Direct Supervisor:  Douglas S. Kwon, MD PhD, Assistant Professor in Medicine
Email: Sarah Eisa, seisa@mgh.harvard.edu
Phone: (857) 268-7009
Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge: BS or international equivalent required; MS preferred.

Years experience required: 2+ years of project management experience in research, Data analysis skills preferred.

Summary:

The Ragon Institute is a highly unique, innovative, and collaborative research center at the forefront of biomedical science. Founded by Massachusetts General Hospital, MIT, and Harvard, the Ragon vision is a bold one: to harness the power of the immune system to prevent and cure human disease on a global scale. This vision is pursued and advanced every day by a group of highly motivated individuals. The Ragon Institute, at every level, depends upon collaboration, compassion, dedication, and innovation.  It is a results-oriented organization that seeks people who not only embrace these values but who thrive in teams and want to work in a dynamic environment.

The Kwon Lab at the Ragon Institute of MGH, MIT, and Harvard is seeking a full-time Project Manager. The person hired will work under the supervision of Dr. Kwon to oversee ongoing and new studies in South Africa related to women’s health, HIV risk, pregnancy outcomes, the vaginal microbiome, and mucosal immunity. The position will involve managing IRB and other regulatory protocols, communication between key stakeholders, data management, interactions with research sponsors, milestone tracking and reporting, and data analysis. Preference for personnel with experience at academic research institutions in project management roles and/or with data management. The overall goal is to support human translational research to help improve the health of women globally, particularly among those living in sub-Saharan Africa.

The Kwon Laboratory (www.kwonlab.org) is located at the Ragon Institute of MGH, MIT and Harvard in Cambridge, MA. The ideal candidate will be motivated, possess strong communication and management skills, and have outstanding organizational ability. This position functions as a critical part of the team and provides ample opportunities to mentor and train, develop new skills, support a mission driven organization, work with international collaborators, and communicate results to the scientific and lay communities while working in a supportive, highly collaborative, and energetic environment within an exceptional research setting with state-of-the-art facilities.

The Kwon lab is committed to providing a diverse, inclusive, and supportive environment; appropriately qualified applicants from all backgrounds will be considered.

Principal Duties and Responsibilities: The Project Manager will work closely with the Senior Program Manager and under the supervision of Dr. Kwon. The candidate will be responsible for:

Regulatory oversight

Communication

Coordinate and Support Studies in South Africa

Qualifications:

• BS or international equivalent required; MS preferred.
• 2+ years of project management experience in research
• Data analysis skills preferred.

Skills/Abilities/Competencies Required:

• Strong understanding of global health and equity in research, demonstrated interest in public health initiatives
• Must demonstrate outstanding project management skills in a clinical research environment
• Ability to manage IRB submissions and regulatory compliance with investigators and other research staff
• Must be highly organized, self-motivated, assertive and takes initiative, with good problem-solving ability
• Ability to work independently and as a team member, in fast-paced, demanding, clinical research environment in an effective and flexible manner.
• Demonstrates desire to learn from and support others.
• Excellent written and verbal communication skills.

Application information: Please send your resume, cover letter, and contact information for three references to Sarah Eisa  seisa@mgh.harvard.edu.