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Open Positions
Sequencing Platform/Lab Manager

 

 

Salary Plan:   Annual

Direct Supervisor:  Douglas S. Kwon, MD PhD, Assistant Professor in Medicine

Email: dkwon@mgh.harvard.edu

Phone: (857) 268-7009

 

Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard

Minimum degree and field of knowledge:  Masters or PhD

Required experience:  2+ years including experience with next generation sequencing

Summary: The Kwon Laboratory at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Cambridge (www.kwonlab.org) is seeking a highly motivated Sequencing Platform/Laboratory Manger.  This position will work closely with the Principal Investigator (PI) conducting patient-oriented translational research involving cutting-edge technologies furthering work recently published by our group in Immunity, The Lancet Infectious Diseases, and Cell Host and Microbe (see further details here).  Laboratory responsibilities include handling and processing human specimens, using novel sequencing technologies to profile transcriptional signatures of isolated cell populations, and characterizing mucosal microbiomes. The Sequencing Platform/Laboratory Manager will also oversee and coordinate the laboratory’s daily operations, train and mentor lab personnel, and ensure compliance with safety and regulatory standards.

 

The ideal candidate will be motivated, possess strong communication and management skills, and have outstanding laboratory experience and ability. This position functions as a critical part of the team and provides ample opportunities to mentor and train, develop new skills, and communicate results to the scientific community through conference presentations and peer-reviewed publications in a supportive, highly collaborative, and energetic environment within an exceptional research setting with state-of-the-art facilities.

 

Job Duties:

Under the direction of the principal investigator, the Lab Manager independently carries out daily activities of the laboratory, including:

 

  • Processing clinical samples for extraction of RNA and DNA, preparation of sequencing libraries, and use of a variety of next generation sequencing platforms
  • Administrate day-to-day operations in the lab, including personnel training, organization, and work-flow optimization
  • Maintaining detailed documentation of experimental work
  • Ensuring quality control of equipment, reagents and extensive biological specimens
  • Working closely within the group and with outside collaborators
  • Maintaining close communications with PI regarding progress

Qualifications:

  • Highly independent and motivated, with the ability to work in a dynamic team environment
  • Excellent organizational skills and attention to detail
  • Laboratory experience required, especially a background in next-generation sequencing
  • Flexibility to occasionally work evenings
  • Computer experience is essential
  • Minimum 3 year commitment

Application information: The position is open immediately. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu.

Postdoctoral Research Fellow - Mucosal Immunology and the Microbiome

 

Direct Supervisor:  Douglas S. Kwon, MD PhD, Assistant Professor in Medicine

Email: dkwon@mgh.harvard.edu

Phone: (857) 268-7009

Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard

Minimum degree and field of knowledge:  PhD and/or MD with experience in immunology

Years experience required:  At least 3 years of doctoral research experience

 

Summary:
The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston has an opening for a highly motivated postdoctoral fellow to study alterations in the microbiome that occur with HIV infection, following up on recent studies published by our group in Immunity, The Lancet Infectious Diseases, and Cell Host and Microbe (see further details here).  This includes examination of the role of the microbiome in the female genital tract and gut and the impact of these changes on host mucosal immunity. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research involving transcriptional and immunologic profiling of mucosal immune populations and the microbiome with the aim of generating new approaches to treat and prevent HIV infection using samples from well characterized cohorts in the U.S. and sub-Saharan Africa. The position will also involve the use of novel in vivo model system, such as germ free and humanized mice.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptional research setting.

Job Duties:
Under the direction of the principal investigator, the applicant will independently carry out activities performing laboratory research. Duties include:

  • Guide research projects through experimental design, conduct of experiments, and analysis of data
  • Maintain detailed documentation of the experimental work
  • Present data within and outside of the laboratory group at meetings and symposia
  • Work closely within the group and with outside collaborators
  • Mentor students and technicians
  • Maintain close communications with the PI regarding progress
  • Write, edit, and submit manuscripts/abstracts detailing the results of the project
  • Demonstrate integrity, excellence, accountability and teamwork in all interactions

 

Qualifications:

  • A Ph.D. and/or M.D. with relevant experience in immunology, murine models, and/or transcriptional profiling preferred
  • Experience with flow cytometry, cell culture
  • Prior work with murine models preferred
  • Highly motivated and independent, with the ability to work in a dynamic team environment
  • Exceptional organizational skills and excellent attention to detail
  • Strong oral and written communications skills
  • Must have good interpersonal skills
  • Occasional weekend or evening flexibility

 

Application information: The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries.  All applicants, including those from abroad, must be able to come to Cambridge, MA USA for an in person interview.

 

Research Technician

 

Salary Plan:   Annual

Direct Supervisor:  Douglas S. Kwon, MD PhD, Assistant Professor in Medicine

Email: dkwon@mgh.harvard.edu

Phone: (857) 268-7009

Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard

Minimum degree and field of knowledge:  BS/BA

Years experience required:  0-2 years of experience

 

Summary: The Kwon Laboratory at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston (www.kwonlab.org) has an opening for a highly motivated Research Technician to study the immunopathogenesis of HIV infection at mucosal tissue sites.  The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research involving cutting-edge technologies. The position will involve handling and processing of tissue and blood samples and utilizing novel assays to study mucosal immune responses against HIV. The project includes transcriptional profiling of isolated cell populations, characterization of innate and adaptive responses, immunofluorescent microscopy, and cellular functional assays.

This is a great opportunity for someone interested in pursuing a career in scientific research or medicine while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptionally energetic research setting.

Job Duties:

Under the direction of the principal investigator, the applicant independently carries out daily activities of the laboratory, including:

  • Maintain detailed documentation of the experimental work
  • Ensure quality control of equipment, reagents and cellular components
  • Work closely within the group and with outside collaborators
  • Perform and assist with experiments involving immunologic assays, microscopy, flow cytometry and molecular biology
  • Maintain close communications with PI regarding progress

Qualifications:

  • Highly motivated and independent, with the ability to work in a dynamic team environment
  • Excellent organizational skills and attention to detail
  • Laboratory experience required, especially tissue culture
  • Flexibility to occasionally work evenings
  • Computer experience is essential
  • 2 year commitment

Application information: The position is open immediately. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu.