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Open Positions:

Postdoctoral Research Fellow - Mucosal Immunology & the Microbiome

Direct Supervisor:  Douglas S. Kwon, MD PhD, Assistant Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge:  PhD and/or MD with experience in immunology
Years experience required:  At least 3 years of doctoral research experience

Summary:
The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston has an opening for a highly motivated postdoctoral fellow to study alterations in the microbiome that occur with HIV infection, following up on recent studies published by our group in ImmunityThe Lancet Infectious Diseases, and Cell Host and Microbe (see further details here).  This includes examination of the role of the microbiome in the female genital tract and gut and the impact of these changes on host mucosal immunity. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research involving transcriptional and immunologic profiling of mucosal immune populations and the microbiome with the aim of generating new approaches to treat and prevent HIV infection using samples from well-characterized cohorts in the U.S. and sub-Saharan Africa. The position will also involve the use of novel in vivo model system, such as germ-free and humanized mice.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptional research setting.

Job Duties:
Under the direction of the principal investigator, the applicant will independently carry out activities performing laboratory research. Duties include:

  • Guide research projects through experimental design, conduct experiments, and analysis of data
  • Maintain detailed documentation of the experimental work
  • Present data within and outside of the laboratory group at meetings and symposia
  • Work closely within the group and with outside collaborators
  • Mentor students and technicians
  • Maintain close communications with the PI regarding progress
  • Write, edit, and submit manuscripts/abstracts detailing the results of the project
  • Demonstrate integrity, excellence, accountability and teamwork in all interactions

Qualifications:

  • A Ph.D. and/or M.D. with relevant experience in immunology, murine models, and/or transcriptional profiling preferred
  • Experience with flow cytometry, cell culture
  • Prior work with murine models preferred
  • Highly motivated and independent, with the ability to work in a dynamic team environment
  • Exceptional organizational skills and excellent attention to detail
  • Strong oral and written communications skills
  • Must have good interpersonal skills
  • Occasional weekend or evening flexibility

Application information: The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries.  All applicants, including those from abroad, must be able to come to Cambridge, MA USA for an in-person interview.

Postdoctoral Research Fellow - Murine Models of Mucosal Immunology

Direct Supervisor:  Doug S. Kwon, MD PhD, Associate Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Website: www.kwonlab.org

Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge: PhD and/or MD with experience in immunology, microbiology and/or computational approaches
Years experience required: At least 3 years of doctoral research experience

Summary:
The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston has an opening for a highly motivated postdoctoral fellow to study mechanistic links between the vaginal microbiome and adverse reproductive outcomes, following up on recent studies published by our group in Immunity, The Lancet Infectious Diseases, and Cell Host and Microbe (see further details here).  This includes examination of the role of the vaginal microbiome that impact host mucosal immunity and HIV acquisition risk. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research using samples from well characterized cohorts in the U.S. and sub-Saharan Africa involving transcriptional and immunologic profiling of mucosal immune populations and the microbiome using novel technologies, with the aim of generating new approaches to treat and prevent HIV infections. This includes the use of novel murine models to perform mechanistic studies of the role of mucosal immunity in the female genital tract on HIV susceptibility.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptional research setting.

Job Duties: Under the direction of the principal investigator, the applicant will independently carry out activities performing laboratory research. Duties include:

  • Guide research projects through experimental design, conduct of experiments, and analysis of data
  • Maintain detailed documentation of the experimental work
  • Present data within and outside of the laboratory group at meetings and symposia
  • Work closely within the group and with outside collaborators
  • Mentor students and technicians
  • Maintain close communications with the PI regarding progress
  • Write, edit, and submit manuscripts/abstracts detailing the results of the project
  • Demonstrate integrity, excellence, accountability and teamwork in all interactions

Ideal Qualifications:

  • A Ph.D. and/or M.D. with relevant experience in immunology and mouse work preferred
  • Experience with flow cytometry, cell culture
  • Highly motivated and independent, with the ability to work in a dynamic team environment
  • Exceptional organizational skills and excellent attention to detail
  • Strong oral and written communications skills
  • Must have good interpersonal skills
  • Prior work with murine models

Application information: The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries. All applicants, including those from abroad, must be able to come to Cambridge, MA USA for an in-person interview.

Research Technician

Direct Supervisor:  Doug S. Kwon, MD PhD, Associate Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Website: www.kwonlab.org

Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree: Bachelor’s degree required
Years experience required: At least 3 years of doctoral research experience
MGH Job Code: 000319 & 001593

Summary:

The Kwon Laboratory at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston (www.kwonlab.org) has an opening for a highly motivated Research Technician to study the immunopathogenesis of HIV infection and the human microbiome at mucosal tissue sites, including the female reproductive tract. The overall goal is to conduct human translational research to help reduce the spread of HIV, particularly among young women in sub-Saharan Africa. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research involving cutting-edge technologies. The position will involve handling and processing of tissue and blood samples, performance of anaerobic bacteriology, immunologic assays, nucleic acid extractions, PCR, sequencing, and utilizing novel assays to study mucosal immune responses to HIV and mucosal bacteria.

This is a great opportunity for someone interested in pursuing a career in scientific research or medicine while working in a supportive, highly collaborative, and energetic environment. The lab studies samples from ongoing clinical cohorts based in the US and South Africa examining risk of HIV, HIV pathogenesis, and other adverse reproductive outcomes. State-of-the-art facilities are available within an exceptionally energetic research setting. Tech would be required to perform experiments analyzing microbial and tissue samples from human subjects, assessing the impact of the microbiome and HIV infection on cervicovaginal mucosal health and perform and assist with experiments involving bacteriology, immunologic assays, microscopy, flow cytometry and molecular biology.

The Kwon lab is committed to providing a diverse, inclusive, and supportive environment; appropriately qualified applicants from all backgrounds will be considered.

Job Duties:

  • Prepares basic solutions and performs base-level procedures as assigned (i.e. – pipetting, cell and tissue culture, etc.)
  • Maintains laboratory notebook
  • Understands and applies basic scientific techniques
  • Conducts analysis of results and may begin interpretation of results
  • Sets up and prepares routine experiments as directed
  • Prepares lab reagents, chemicals, instruments and equipment
  • May perform independent literature searches
  • Assists with organizing materials for publication or presentation
  • Maintains and orders supplies

A Research Technician II performs the duties of a Research Technician I (above) and may also:

  • Execute protocols of non-routine experiments
  • Assist the PI(s) with determining the most suitable methodology
  • Perform basic design and modification of protocols
  • Calculate, transcribe and analyze data
  • Prepare and present reports
  • Organize and summarize acquired data, using scientific and statistical techniques.
  • Organize and/or draft material for the preparation of research papers, manuscripts and other documents for publication and/or presentation.
  • Participate in the design of experiments or field work.


Ideal Qualifications:

  • Ability to work independently and as a team member
  • Good communication skills
  • Computer literacy
  • Working knowledge of clinical research protocols
  • Ability to perform multiple tasks independently

Application information: The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries.

Staff Assistant

Direct Supervisors:    Douglas Kwon, M.D. Ph.D. & Shiv Pillai, M.D., Ph.D.
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Website: www.kwonlab.org

Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge: B.S. or B.A.
Years experience required: 0 – 2 years experience
Salary Plan: Full time, 40 hours/week

Summary:
This position is located at the Ragon Institute in Cambridge, MA and is a part of Massachusetts General Hospital, MIT, and Harvard Medical School. We are a results-oriented group of highly motivated scientists from the fields of immunology, virology, genetics, vaccinology, and technology development who perform translational research to treat and prevent HIV. At every level, we value intelligence, teamwork, dedication and creativity, and we’re always looking for people with those skills who thrive in teams and dynamic environments.

Reporting to Dr. Kwon (www.kwonlab.org) and Dr. Shiv Pillai, the Staff Assistant provides a wide range of administrative support and project management including: calendar management, purchasing and order tracking for laboratory supplies, expense reporting, assisting in grant preparation and submission, onboarding and training of new hires, all aspects of travel arrangements for the principal investigators, planning lab seminars and lab retreats, and serving as a key point of contact for both PI’s in a professional, courteous, and helpful manner.

The role also includes occasionally serving as project lead for the planning of educational workshops taught by Dr. Shiv Pillai and Dr. Doug Kwon, including planning all aspects of international travel, accommodation, management of course advertisement, student enrollment, financial management, coordination with donor institutions, and all coordination of catering, IT services, and student support onsite.

Job Duties:

  • Provide overall administrative support for two senior faculty members, responsibilities include calendar management, scheduling meetings and teleconferences, and arranging domestic/international travel
  • Perform assorted administrative tasks and miscellaneous errands as needed
  • Process expense reports, invoices, vendor check requests, and advanced authorization requests for special events
  • Assist with prospective applicant onboarding and new-hire support
  • Work with regulatory staff to ensure compliance with research regulatory matters
  • Act as liaison between PI, lab personnel, and external partners and administrators
  • Manage the Lab website

Qualifications:

  • Excellent calendar and time management skills, and the ability to manage complex operations in a fast-paced environment
  • Proficiency in Microsoft Office required
  • Executive-level interpersonal skills needed to interact with all levels of management and staff
  • Excellent organizational skills and the ability to prioritize multiple tasks, projects and assignments
  • Experience with event planning and scheduling travel arrangements preferred
  • Professional demeanor, proactive, resourceful and efficient in all tasks
  • Flexibility, adaptability to work in a changing environment required; occasional evening and weekend work related to special events and meetings may be required

Additional Qualifications:
Must possess superior organizational and communication skills. Candidate must be able to take initiative, to work independently and as part of a team, to prioritize tasks and complete assignments with accuracy. Should have strong written and oral communication skills and be capable of preparing draft correspondence.

Application information:
The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries.

The above job description details the major duties and qualifications of the listed position. The employee hired to this position confirms that he/she is able to perform all duties outlined. Although the specific duties and responsibilities of this position may vary slightly, the supervisor of this position will ensure that the employee hired to this position is trained and qualified to complete each task assigned. If the duties or responsibilities of this position need to change significantly, then the supervisor must submit an updated job description to the Office Manager for review.