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Join Our Team!

Join Our Team!

 

 

 

 

 

 

Open Positions:

Postdoctoral Research Fellow - Mucosal Immunology & the Microbiome

Direct Supervisor:  Douglas S. Kwon, MD PhD, Assistant Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge:  PhD and/or MD with experience in immunology
Years experience required:  At least 3 years of doctoral research experience

Summary:
The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston has an opening for a highly motivated postdoctoral fellow to study alterations in the microbiome that occur with HIV infection, following up on recent studies published by our group in ImmunityThe Lancet Infectious Diseases, and Cell Host and Microbe (see further details here).  This includes examination of the role of the microbiome in the female genital tract and gut and the impact of these changes on host mucosal immunity. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research involving transcriptional and immunologic profiling of mucosal immune populations and the microbiome with the aim of generating new approaches to treat and prevent HIV infection using samples from well-characterized cohorts in the U.S. and sub-Saharan Africa. The position will also involve the use of novel in vivo model system, such as germ-free and humanized mice.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptional research setting.

Job Duties:
Under the direction of the principal investigator, the applicant will independently carry out activities performing laboratory research. Duties include:

  • Guide research projects through experimental design, conduct experiments, and analysis of data
  • Maintain detailed documentation of the experimental work
  • Present data within and outside of the laboratory group at meetings and symposia
  • Work closely within the group and with outside collaborators
  • Mentor students and technicians
  • Maintain close communications with the PI regarding progress
  • Write, edit, and submit manuscripts/abstracts detailing the results of the project
  • Demonstrate integrity, excellence, accountability and teamwork in all interactions

Qualifications:

  • A Ph.D. and/or M.D. with relevant experience in immunology, murine models, and/or transcriptional profiling preferred
  • Experience with flow cytometry, cell culture
  • Prior work with murine models preferred
  • Highly motivated and independent, with the ability to work in a dynamic team environment
  • Exceptional organizational skills and excellent attention to detail
  • Strong oral and written communications skills
  • Must have good interpersonal skills
  • Occasional weekend or evening flexibility

Application information: The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries.  All applicants, including those from abroad, must be able to come to Cambridge, MA USA for an in-person interview.

Postdoctoral Research Fellow - Murine Models of Mucosal Immunology

Direct Supervisor:  Doug S. Kwon, MD PhD, Associate Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Website: www.kwonlab.org

Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge: PhD and/or MD with experience in immunology, microbiology and/or computational approaches
Years experience required: At least 3 years of doctoral research experience

Summary:
The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston has an opening for a highly motivated postdoctoral fellow to study mechanistic links between the vaginal microbiome and adverse reproductive outcomes, following up on recent studies published by our group in Immunity, The Lancet Infectious Diseases, and Cell Host and Microbe (see further details here).  This includes examination of the role of the vaginal microbiome that impact host mucosal immunity and HIV acquisition risk. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research using samples from well characterized cohorts in the U.S. and sub-Saharan Africa involving transcriptional and immunologic profiling of mucosal immune populations and the microbiome using novel technologies, with the aim of generating new approaches to treat and prevent HIV infections. This includes the use of novel murine models to perform mechanistic studies of the role of mucosal immunity in the female genital tract on HIV susceptibility.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptional research setting.

Job Duties: Under the direction of the principal investigator, the applicant will independently carry out activities performing laboratory research. Duties include:

  • Guide research projects through experimental design, conduct of experiments, and analysis of data
  • Maintain detailed documentation of the experimental work
  • Present data within and outside of the laboratory group at meetings and symposia
  • Work closely within the group and with outside collaborators
  • Mentor students and technicians
  • Maintain close communications with the PI regarding progress
  • Write, edit, and submit manuscripts/abstracts detailing the results of the project
  • Demonstrate integrity, excellence, accountability and teamwork in all interactions

Ideal Qualifications:

  • A Ph.D. and/or M.D. with relevant experience in immunology and mouse work preferred
  • Experience with flow cytometry, cell culture
  • Highly motivated and independent, with the ability to work in a dynamic team environment
  • Exceptional organizational skills and excellent attention to detail
  • Strong oral and written communications skills
  • Must have good interpersonal skills
  • Prior work with murine models

Application information: The position is open immediately although the start date is flexible. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu. Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries. All applicants, including those from abroad, must be able to come to Cambridge, MA USA for an in-person interview.

Bioinformatics Analyst

Direct Supervisor:  Douglas S. Kwon, MD PhD, Associate Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge: BS/BA/BEng
Years of experience required: 2 years of computational biology experience or a relevant Masters degree

Summary:
The Kwon Laboratory at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Boston (www.kwonlab.org) has an opening for a Bioinformatics Assistant in Microbiome Research to aid in analyzing shotgun and rRNA 16S metagenomic data. The person hired will work on conducting patient-oriented translational research involving cutting-edge technologies studying the interaction between microbial strains and the mucosal immune system of the human reproductive tract.

Job Duties: Under the direction of the principal investigator, the associated responsibilities will include:

  • Analyze data from high-throughput, massively parallel genomic and/or clinical data sets using existing software applications
  • Design, develop, and implement minor enhancements to analysis and visualization tools
  • Train other lab members on commonly used bioinformatics applications
  • Assists in the development of bioinformatics workflows to automate frequently used analytical procedures
  • Provide summary reports of workflow outputs
  • Maintain detailed documentation either through a laboratory notebook or well annotated scripts
  • Be an active member of the Kwon Lab, including participating in meetings and regularly presenting results
  • Maintain close communications with PI regarding progress, including timely reporting of issues, needs and risk associated with project completion

Qualifications:

  • Essential skills:
    • Ability to analyze and interpret large complex data sets and to communicate data in a clear and concise manner
    • Proficiency in Unix and the ability to script in Python and perform statistical analyses in R
    • The ability to install and execute software from the Linux command line
    • The ability to construct, document and execute analytical workflows
  • Desirable skills:
    • Experience processing and analyzing metagenomics data (16S and shotgun)
    • An understanding of statistical modelling
  • Soft skills:
    • Strong analytical, reasoning and problem-solving skills
    • Highly motivated and independent, with the ability to work in a dynamic team environment
    • Excellent organizational skills, attention to detail and time management

Application information: The position is open immediately. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu.

Research Technician II - Sequencing Core

Direct Supervisor:  Doug S. Kwon, MD PhD, Associate Professor in Medicine
Email: dkwon@mgh.harvard.edu
Phone: (857) 268-7009
Website: www.kwonlab.org
Employing Hospital and Department: Ragon Institute of MGH, MIT, and Harvard

Summary:
The Kwon Laboratory at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Cambridge (www.kwonlab.org) has an opening for a highly motivated Research Technician to study the immunopathogenesis of HIV infection at mucosal tissue sites. The person hired will work under the supervision of Dr. Kwon, conducting patient-oriented translational research using next generation sequencing technologies to support multiple projects within a highly collaborative and dynamic group. The position will involve handling and processing microbial samples from gut, the female genital tract, saliva, skin, and blood. The technician will perform and assist with experiments involving molecular biology such as nucleic acids extractions, sequencing library construction, next generation sequencing and computational analysis. Previous experience with Illumina sequencing platforms is a plus, as is experience with bioinformatics tools such as R or Python.
This is a great opportunity for someone interested in pursuing a career in scientific research or medicine while working in a supportive, highly collaborative, and energetic environment.  State-of-the-art facilities are available within an exceptionally energetic research setting.

Principal duties and responsibilities:

  • Perform and assist with experiments involving molecular biology such as nucleic acids extractions, sequencing library contruction, and next generation sequencing
  • Analyze data using computational methods
  • Maintain detailed documentation of the experimental work
  • Ensure quality control of equipment, reagents and lab space
  • Participates in the training of technical staff and students
  • Work closely within the group and with outside collaborators
  • Maintain close communications with PI regarding progress

Qualifications:

  • Highly motivated, dedicated and independent, with the ability to work in a dynamic team environment
  • Excellent organizational skills and attention to details
  • Strong communication and interpersonal skills
  • Laboratory experience required, especially sample processing and molecular techniques
  • Flexibility to occasionally work at evenings and weekends
  • Computer experience is essential, and experience with bioinformatics tools such as R and Python is a plus
  • Prior work with Illumina sequencing platforms is a plus
  • Bachelor’s degree required
  • Those with a minimum of 1 year of directly related work experience will be considered for a Research Technician II position.

Application information: The position is open immediately. Please submit a cover letter, CV, and references to Dr. Doug Kwon at dkwon@mgh.harvard.edu.